
Just set the equalizer to something that looks close to this, then select "set preset..." in the drop-down menu and call it perfect.
Yay! Most songs sound better this way!
The only problem with this (or any default equalizer setting, really) is that it sometimes amplifies things were quieter in the recording for a reason. Case in point, the Radiohead track "Kid A" has a background rhythmic static track that overwhelms the mix with this equalizer enabled on small speakers. The good news is that there is an easy way to fix this.
First, tune the equalizer to this flat one and set it as "No change." Make sure that after you make this preset you reset the equalizer to "Perfect."
Notice that the preset has a pre-amp setting. This is so it fits a little better with the tracks set to perfect.
Now when you hear a track that sounds kind of funky with the "Perfect" setting enabled right click it in the iTunes browser and select "Get Info." Go to the "Options" tab on the top and change the "Equalizer Preset" setting to the "No change" preset.
Now if you have the equalizer setting set to "Perfect" normally it will change to "No change" whenever that song comes up and then revert to "Perfect" afterwards.
This is the lazy way to do it, if you want to get a little more fancy you can change the preset for songs that don't work with "Perfect" to a preset that isn't flat but is more appropriate for the song.